USAID's programs in Guyana are managed out of USAID's Eastern and Southern Caribbean Mission.

In Guyana, USAID programs focus on health, economic growth, and democracy and governance.

The health program strengthens public health systems and works to ensure the availability of comprehensive care; enhances civil-society and private-sector responses to HIV/AIDS; provides HIV prevention services; and improves supply-chain management of drugs and other supplies. 

Economic growth activities strengthen the capacity of Guyana's private sector, and support increased investments in non-traditional exports within four sectors: wood products, aquaculture, agribusiness and ecotourism.

USAID support has also improved institutions and systems in the areas of rule of law, good governance, political competition and consensus building, and civil society. In addition, a project funded by the Caribbean Basin Security Initiative helps reduce youth violence by engaging at-risk youth in job and civic opportunities.