The effects of health systems strengthening on health status and related outcomes, have not been comprehensively reviewed or captured in a single document. To address this knowledge gap, the Health Finance and Governance (HFG) Project conducted a review of published systematic literature reviews that assessed the effects of health systems strengthening interventions on health status and health system outcomes (service utilization, quality service provision, uptake of healthy behaviors, and financial protection) in low- and middle-income countries (LMICs).