Advances in science and innovative service delivery models have made ending the HIV epidemic a possibility by increasing access to HIV testing, biomedical interventions, and antiretroviral medications, thereby preventing new infections among individuals at greatest risk.  In many countries across Asia and the Pacific, new HIV infections each year among key populations (KP)—people who inject drugs, men who have sex with men (MSM), sex workers, and transgender people-—are far higher than the general population, yet the number of people in these KPs accessing HIV services remains very low.  With funding from the President’s Emergency Plan for AIDS Relief (PEPFAR), the U.S. Agency for International Development Regional Development Mission for Asia (USAID/RDMA) works to control the epidemic by using more effective methods to reach, test, treat, and retain these KPs in key services.